sustanon cycle

Pharmacotherapeutic group : intestinal antiseptic and astringent.

pharmacological properties

Pharmacodynamics
Antiulcer agent with bactericidal activity against Helicobacter pylori. It has also anti-inflammatory and astringent. In the acidic environment of the stomach precipitated insoluble bismuth oxychloride and citrate chelated compound formed from a proteinaceous substrate a protective film on the surface of ulcers and erosions. By increasing the synthesis of prostaglandin E, mucus and bicarbonate secretion, it stimulates the activity of cytoprotective mechanisms increases resistance mucosa of the gastrointestinal tract to the action of pepsin, hydrochloric acid, enzymes and bile salts. It leads to the accumulation of epidermal growth factor in the defect zone. Reduces the activity of pepsin and pepsinogen.

Pharmacokinetics of
bismuth subcitrate is practically not absorbed from the gastrointestinal tract. Write mainly faeces. A small amount of bismuth, received by the plasma removed from the body by the kidneys.

Indications

Gastric ulcer and duodenal ulcer in the acute phase, including those associated with Helicobacter pylori.
Chronic gastritis and gastroduodenitis in the acute phase, including those associated with Helicobacter pylori.
Irritable bowel syndrome, flowing mostly with symptoms of diarrhea.
Functional dyspepsia is not related to organic diseases of the gastrointestinal tract.

Contraindications

Severe renal failure, pregnancy, lactation, hypersensitivity to the drug.

Dosing and Administration

Adults and children over 12 years of drug prescribed 1 tablet 4 times a day 30 minutes before meals and at bedtime or 2 sustanon cycle 2 times a day 30 minutes before meals. Children from 8 to 12 years of drug prescribed for . 1 tablet 2 times a day 30 minutes before meals Children from 4 to 8 years: prescribe a dose of 8 mg / kg / day; daily dose is divided into 2 admission. Take 30 minutes before meals. sustanon cycle should be washed down with a little water. The duration of treatment of 4-8 weeks. During the next eight weeks should not apply the preparations containing bismuth. For eradication of Helicobacter pylori is advisable to use De Nol in combination with other antibacterial agents having activity of H. pylori.

Side effect

From the digestive system: may cause nausea, vomiting, more frequent stools, constipation. These phenomena are not dangerous to health and are temporary in nature. Allergic reactions: skin rash, itching of the skin. With long-term use at high doses – encephalopathy is associated with the accumulation of bismuth in the CNS.

Overdose of the drug

Overdose of the drug caused by long-term use of doses higher than recommended may lead to impaired renal function. These symptoms are completely reversible when canceling De-Nol.
When the poisoning symptoms the drug should be gastric lavage, use activated charcoal and saline laxatives. In the future, the treatment should be symptomatic. In case of renal dysfunction, accompanied by high levels of bismuth in the blood plasma, it is possible to enter the complexing agents – dimerkaptoyantarnuyu and dimerkaptopropansulfonovuyu acid. In the case of severe impaired renal function is shown hemodialysis.

Interaction with other drugs

Within half an hour before and after taking the De Nola is not recommended to use inside other drugs, as well as reception of food and fluids, in particular, antacids, milk, fruits and fruit juices. This is due to the fact that they are at, while ingestion may affect the efficiency of De-Nol.

special instructions

The drug should not be used more than 8 weeks. It is also not recommended during treatment exceed the daily dose for adults and children. During treatment De nolom should not be used other drugs containing bismuth. Upon completion of a course of drug treatment at the recommended doses of active plasma concentration of the active substance does not exceed 3-5,8 g / l, and the toxicity is observed only at concentrations above 100 mg / l.
When applying De Nol possible fecal staining due to the dark color education bismuth sulfide. Sometimes there is a slight darkening of the tongue,

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